Immunohistochemical Staining for TLE1 Distinguishes Synovial Sarcoma From Histologic Mimics
نویسندگان
چکیده
منابع مشابه
TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies.
Synovial sarcoma is a soft tissue malignancy defined by the SYT-SSX fusion oncogene. Demonstration of the t(X;18) by cytogenetics, fluorescence in situ hybridization or reverse-transcriptase polymerase chain reaction has become the gold standard for diagnosis, but practical considerations limit the availability of these methods. Gene expression profiling studies performed by several independent...
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The histologic distinction between meningiomas and other tumors of the central nervous system occasionally can be difficult. Claudin-1 is a tight junction-associated protein recently shown to be expressed in anaplastic meningiomas. The purpose of this study was to determine whether immunohistochemical staining for claudin-1 could help distinguish meningiomas from histologic mimics, compared wit...
متن کاملImmunohistochemical validation of TLE1, a novel marker, for synovial sarcomas
BACKGROUND & OBJECTIVES Logistic and financial constraints limit application of several available immunohistochemical (IHC) markers and molecular analysis in every case of synovial sarcoma, diagnosed in our settings. Recently, TLE1 has been recognized as a robust IHC marker for diagnosing a synovial sarcoma. Here, we present IHC features of synovial sarcomas, including TLE1 expression in these ...
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Synovial sarcoma is a relatively common soft tissue malignancy that is characterized by a specific chromosomal t(X;18)(p11;q11) translocation. Transducin-like enhancer of split 1 (TLE1) has emerged as a useful marker for the diagnosis of synovial sarcoma. However, the diagnostic value of this antibody remains controversial. We investigated TLE1 expression in sixty-two fluorescence in situ hybri...
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The clinical, radiological and pathologic features of a biphasic synovial sarcoma in the left elbow joint of a two-year-old male Rottweiler are presented. The tumor showed positive immunoreactivity for vimentin, Epithelial Membrane Antigen (EMA), p53 and PCNA, while it was negative for the cytokeratin used, S-100, Rb and p21. Immunohistochemistry for EMA allowed the identification of epithelioi...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2011
ISSN: 0002-9173,1943-7722
DOI: 10.1309/ajcp45ssnaopxyxu